Thirteen‐week Inhalation Toxicity of Carbon Tetrachloride in Rats and Mice

Thirteen-week inhalation toxicity of carbon tetrachloride in rats and mice.

Subchronic toxicity of carbon tetrachloride (CCl4) was examined by inhalation exposure of F344 rats and BDF1 mice of both sexes to 0, 10, 30, 90, 270 or 810 ppm (v/v) CCl4 vapor for 13 wk (6 h/d and 5 d/wk). In the high exposure levels at 270 and 810 ppm, altered cell foci in the livers of both rats and mice, and fibrosis and cirrhosis in the rat liver were observed. Hematoxylin and eosin-stain...

Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice

Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...

Crocin mitigates carbon tetrachloride-induced liver toxicity in rats

Objectives: Carbon tetrachloride (CCl4) is one of the most dangerous hepatotoxic environmental pollutants thus this study aimed at investigating the potential preventive effect and mechanism of crocin against CCl4induced hepatotoxicity. Methods: Forty Male rats were allocated for two weeks treatment with; corn oil, CCl4 in corn oil, crocin (100 mg/ kg), or crocin plus CCl4. At time of euthanasi...

[Anuria caused by inhalation of carbon tetrachloride].

The Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Rats

Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous ...